Abstract. The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's
Apolipoprotein E epsilon 4 genotype and a physically active lifestyle in late life: analysis of gene–environment interaction for the risk of dementia and Alzheimer's disease dementia - Volume 44 Issue 6. Skip to main content Accessibility help The presence of the ε4 allele,
Although we did not find a gene–environment interaction for general dementia risk, a protective effect of physical activity on the risk for dementia was found in both APOE ε 4 allele carriers and non-carriers. Results: The presence of at least one epsilon 4 allele was associated with faster cognitive decline in the incident population-based AD group (p = 0.01). Parallel results were produced for the two prevalent dementia samples only when adjusting for disease severity or excluding the most impaired participants from the analyses. RESEARCH ARTICLE APOE epsilon-4 allele and cytokine production in Alzheimer’s disease Paolo Olgiati 1, Antonis Politis 2, Petros Malitas 3, Diego Albani 4, Sabrina Dusi 4, Letizia Polito 4, Stefania De Mauro4, Aikaterini Zisaki5, Christina Piperi5, Evangelia Stamouli2, Antonis Mailis2, Sara Batelli4, Gianluigi Forloni 4, Diana De Ronchi 1, Anastasios Kalofoutis 6,7, Ioannis Liappas 8 and AB - Objective: The APOE epsilon-4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD).
2.8%). A significant increased risk of AD among APOE ε4 allele carriers was observed. The odds ratio for the association of AD patients with homozygous and heterozygous ε4 allele was, respectively, 5.40 (1.35–21.48) and 2.90 (1.27–6.62). 2005-11-01 · DENVER -- The well-documented association between the apolipoprotein E [epsilon]4 allele and development of cognitive decline and Alzheimer's disease may be mediated at least in part by obstructive sleep apnea, Ruth O'Hara, Ph.D., said at the annual meeting of the Associated Professional Sleep Societies. De très nombreux exemples de phrases traduites contenant "epsilon-4 allele" – Dictionnaire français-anglais et moteur de recherche de traductions françaises. We analyzed published data sequentially first considering epsilon 4 allele itself, and then epsilon 4 carrier status as risk factors for schizophrenia using a sample of 17 population-based case-control studies, of which 6 were from Asian and 11 from Caucasian populations.
Contrary to previous reports, no effect of the dosage of the {epsilon}4 allele was found on the age of onset of dementia among the AD cases and, contrary to reports suggesting an association of {epsilon}4 and atherosclerosis, the {epsilon}4 allele frequency was similar in cases with or without concurrent brain infarcts.
[1] reported that survival from onset was unrelated to epsilon 4 gene dose. In this issue, Kurz et al.
Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: The Suita Study Katsuya, Tomohiro a ; Baba, Shunroku b ; Ishikawa, Kazuhiko a ; Mannami, Toshifumi b ; Fu, Yuxiao a ; Inamoto, Nozomu a ; Asai, Takashi a ; Fukuda, Masayuki a ; Higaki, Jitsuo a ; Ogata, Jun b ; Ogihara, Toshio a
From clinically based series it has been proposed that, in homozygotes for the apolipoprotein E epsilon 4 (apoE epsilon 4) allele, Alzheimer's disease is almost inevitable by the age of 80. A population sample of persons aged 70 years and over was interviewed in 1990-91 to ascertain the presence of dementia or cognitive impairment. diseases. RESULTS: APOE allele frequency in the total group was epsilon 2 = 7.8%, epsilon 3 = 76.4% and epsilon 4 = 15.8%. Age, living condition, years of education and APOE epsilon 4 were significant covariates in edentulous subjects (p The odds ratio for AD in individuals with either one or two epsilon 4 was 2.96 (95% CI 1.11 to 8.03). The linear trend for AD in proportion to alleles of epsilon 4 was also significant (chi squared = 8.2, p = 0.004). Our results support the association between epsilon 4 and AD in the Chinese. NEUROLOGY 1996;46: 1749-1751
an, we performed a large genetic epidemiological survey (the Suita Study). Design and methods The Suita Study was a cohort study based on a random sample of 14 200 Japanese residents of Suita city. Subjects who gave informed consent for genetic analysis were recruited in the current study (n = 3997). APOE polymorphism was clearly determined by the TaqMan polymerase chain reaction method
Carriers of an epsilon 4 allele (E4) of apolipoprotein E (APOE) develop Alzheimer's disease (AD) earlier than carriers of other APOE alleles. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration, 5(2), 194-195. Lower Prevalence of Epsilon 4 Allele of Apolipoprotein E Gene in Healthy, Longer-Lived Individuals of Hellenic Origin January 2007 The Journals of Gerontology Series A Biological Sciences and
The APOE epsilon 4 allele is associated with cognitive decline and the development of dementia in the general population as well as in patients with TBI. These findings raise the question of whether patients with TBI who are APOE epsilon 4 allele carriers are more vulnerable to the negative effects of sleep apnea on their cognitive functioning. Apolipoprotein epsilon 4 allele modifies waist-to-hip ratio effects on cognition and brain structure David Zade, Alexa Beiser, Regina McGlinchey, Rhoda Au, Sudha Seshadri, Carole Palumbo, Philip A. Wolf, Charles DeCarli , William Milberg
28 Jan 2016 The APOE gene consists of four exons and three introns and is polymorphic on two single nucleotides resulting in three different alleles (ε2, ε3
27 May 2019 The ε4 allele status has been associated with brain structural brain atrophy in cognitively intact adults with a single APOE epsilon 4 allele. 8 May 2020 The apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to
There are at least three slightly different versions (alleles) of the APOE gene. Nigerians. The alleles of apoE appear to have a role in the etiology of AMD, with the ε4 allele The apolipoprotein E epsilon 4 allele is unlikely to be a major risk factor of
Four of these studies did not find an association between the APOE ɛ4-allele and the presence of delirium, although two studies found a relation between the
15 Jan 1997 Patients with either one or two apoE ε4 alleles not only showed a more (1995) Apolipoprotein epsilon4 allele and disease progression in
Human apoE is a polymorphic protein with three common alleles, APO epsilon 2, APO epsilon 3, and APO epsilon 4. ApoE4 is associated with sporadic and
Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults. Neurology. Subjects who gave informed consent for genetic analysis were recruited in the current study (n = 3997). APOE polymorphism was clearly determined by the TaqMan polymerase chain reaction method
Carriers of an epsilon 4 allele (E4) of apolipoprotein E (APOE) develop Alzheimer's disease (AD) earlier than carriers of other APOE alleles. The APOE-epsilon 4 allele is the strongest known genetic risk factor for AD. The authors performed a meta-analysis to establish the predictive accuracy of the APOE-epsilon 4 allele for progression from MCI to AD-type dementia. Compared with the epsilon 3 allele, the epsilon 4 allele was associated with elevated low-density lipoprotein cholesterol values (> or = 4.14 mmol/L [160 mg/dL]) in women, the epsilon 2 and
RESEARCH ARTICLE APOE epsilon-4 allele and cytokine production in Alzheimer’s disease Paolo Olgiati 1, Antonis Politis 2, Petros Malitas 3, Diego Albani 4, Sabrina Dusi 4, Letizia Polito 4, Stefania De Mauro4, Aikaterini Zisaki5, Christina Piperi5, Evangelia Stamouli2, Antonis Mailis2, Sara Batelli4, Gianluigi Forloni 4, Diana De Ronchi 1, Anastasios Kalofoutis 6,7, Ioannis Liappas 8 and
PY - 2010/4/1. Y1 - 2010/4/1. N2 - Objective: The APOE epsilon-4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD). Pro-inflammatory cytokines are detectable at abnormal levels in AD, and are thought to play a pathophysiological role.
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brain. APOE gene regulates the expression of this protein and has three different alleles: ε2, ε3 and ε4. Carrying an APOE4 allele is recognised as a genetic risk factor of late-onset Alzheimer’s disease (LOAD) and coronary heart disease (CHD). Consuming fatty fish, rich